Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 14/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24568636 | 0.78 | ADORA3 (0.34) | — | |
| SCHEMBL23970708 | 0.75 | GRM5 (0.37) | NR1H2NR1H3PRMT5TRPV3MEN1 | |
| SCHEMBL29642333 | 0.75 | GRM5 (0.37) | NR1H2NR1H3PRMT5TRPV3MEN1 | |
| SCHEMBL29642207 | 0.73 | GPR119 (0.40) | PRMT5MEN1KMT2AGPR119 | |
| SCHEMBL23971336 | 0.73 | GPR119 (0.40) | PRMT5MEN1KMT2AGPR119 | |
| SCHEMBL29642241 | 0.73 | LMNA (0.36) | NR1H2NR1H3 | |
| SCHEMBL23970707 | 0.73 | LMNA (0.36) | NR1H2NR1H3 | |
| SCHEMBL31233726 | 0.62 | MAPK1 (0.44) | PRMT5MEN1KMT2AGPR119 | |
| SCHEMBL31233725 | 0.62 | MAPK1 (0.44) | PRMT5MEN1KMT2AGPR119 | |
| SCHEMBL4783033 | 0.62 | NR1H2 (0.53) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140428-A2 | INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2022-06-30 | — | — | WO | disclosed |