Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29888300 | 1.00 | PKM (0.47) | PKMMAPTHTTMAPK1POLB | |
| SCHEMBL29888172 | 0.85 | L3MBTL1 (0.46) | PKMMAPTHTTMAPK1POLB | |
| SCHEMBL24570249 | 0.85 | L3MBTL1 (0.46) | PKMMAPTHTTMAPK1POLB | |
| SCHEMBL29888404 | 0.83 | ALDH1A1 (0.42) | PKMMAPTHTTMAPK1POLB | |
| SCHEMBL11797084 | 0.82 | PKM (0.64) | PKMMAPTHTTMAPK1POLB | |
| SCHEMBL24569468 | 0.81 | MAPT (0.47) | MAPTHTTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL29025843 | 0.80 | ALDH1A1 (0.41) | PKMMAPTHTTMAPK1POLB | |
| SCHEMBL24569905 | 0.78 | ALDH1A1 (0.40) | PKMMAPTHTTBRD4ALDH1A1 | |
| SCHEMBL29887828 | 0.78 | ALDH1A1 (0.40) | PKMMAPTHTTBRD4ALDH1A1 | |
| SCHEMBL24167435 | 0.77 | MEN1 (0.46) | MAPTHTTMAPK1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |