Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24740776 | 0.91 | PSMB5 (0.44) | PSMB5 | |
| SCHEMBL21745681 | 0.78 | PSMB5 (0.33) | PSMB5 | |
| SCHEMBL3965918 | 0.78 | LRRK2 (0.33) | — | |
| SCHEMBL38651988 | 0.78 | — | — | |
| SCHEMBL24574595 | 0.78 | PDE10A (0.38) | — | |
| SCHEMBL25859784 | 0.75 | CYP11B1 (0.33) | PSMB5 | |
| SCHEMBL25790850 | 0.75 | OPRK1 (0.31) | — | |
| SCHEMBL25778898 | 0.75 | NOS3 (0.31) | PDK2PDK4 | |
| SCHEMBL24740774 | 0.71 | HCRTR1 (0.31) | — | |
| SCHEMBL3966598 | 0.71 | TDO2 (0.39) | PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102100-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2023-06-08 | — | — | WO | disclosed |
| WO-2022212819-A1 | INDAZOLE DERIVATIVES AS ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2022-10-06 | — | — | WO | disclosed |
| WO-2022140499-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2022-06-30 | — | — | WO | disclosed |