Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24576905 | 0.91 | NR3C1 (0.35) | NR3C1P2RX7 | |
| SCHEMBL30566537 | 0.82 | PIM3 (0.39) | — | |
| SCHEMBL24577968 | 0.82 | IKBKE (0.35) | NR3C1IRAK4JAK2NTRK1 | |
| SCHEMBL29760011 | 0.82 | IKBKE (0.35) | NR3C1IRAK4JAK2NTRK1 | |
| SCHEMBL24577656 | 0.80 | NR3C1 (0.35) | NR3C1P2RX7IRAK4 | |
| SCHEMBL24576990 | 0.77 | IKBKE (0.41) | JAK2 | |
| SCHEMBL24577107 | 0.76 | NR3C1 (0.33) | NR3C1IRAK4 | |
| SCHEMBL29759921 | 0.76 | NR3C1 (0.34) | NR3C1P2RX7IRAK4 | |
| SCHEMBL24577986 | 0.76 | NR3C1 (0.34) | NR3C1P2RX7IRAK4 | |
| SCHEMBL30566505 | 0.72 | JAK1 (0.39) | IRAK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |