Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 6/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 5/20 | 0.37 |
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | LIPC | P11150 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | HAT1 | O14929 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577992 | 0.90 | IKBKE (0.42) | IKBKETBK1BACE1KDM5BLIPC | |
| SCHEMBL30566490 | 0.86 | PDK2 (0.41) | IKBKETBK1JAK3JAK2JAK1 | |
| SCHEMBL29759678 | 0.83 | KDM1A (0.38) | JAK3JAK2JAK1KDM5BLIPC | |
| SCHEMBL24577471 | 0.81 | BACE1 (0.40) | IKBKETBK1BACE1JAK2KDM5B | |
| SCHEMBL30566481 | 0.81 | JAK1 (0.35) | JAK3JAK2JAK1 | |
| SCHEMBL24576870 | 0.81 | MKNK1 (0.41) | JAK3JAK1 | |
| Hydrochloric Acid SCHEMBL30566474 | 0.80 | MKNK1 (0.41) | JAK3JAK1 | |
| SCHEMBL24578823 | 0.80 | IKBKE (0.48) | IKBKETBK1BACE1JAK3JAK2 | |
| SCHEMBL29759699 | 0.80 | IKBKE (0.48) | IKBKETBK1BACE1JAK3JAK2 | |
| SCHEMBL30566531 | 0.80 | TGFBR1 (0.34) | JAK3JAK1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |