Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24579116 | 0.88 | — | — | |
| SCHEMBL29759692 | 0.75 | TGFBR1 (0.42) | HPGDALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL24577485 | 0.75 | TGFBR1 (0.42) | HPGDALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL30809477 | 0.73 | HPGD (0.41) | HPGDALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL30809480 | 0.73 | HPGD (0.41) | HPGDALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL24577381 | 0.70 | ALDH1A1 (0.40) | HPGDALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL24577809 | 0.68 | TGFBR1 (0.43) | HPGDALDH1A1KDM4EMAPTLMNA | |
| Hydrochloric Acid SCHEMBL29759531 | 0.68 | TGFBR1 (0.42) | HPGDALDH1A1KDM4EMAPTLMNA | |
| Hydrochloric Acid SCHEMBL30566615 | 0.68 | TGFBR1 (0.42) | HPGDALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL24577223 | 0.67 | MAPT (0.40) | HPGDALDH1A1KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |