Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2458075 | 0.86 | GPR119 (0.49) | GPR119TRPV4KCNH2KDM1AHRH1 | |
| SCHEMBL2458138 | 0.85 | GPR119 (0.41) | GPR119TRPV4CHRM2CHRM5CHRM1 | |
| SCHEMBL14237689 | 0.82 | GPR119 (0.37) | GPR119CHRM2CHRM5CHRM1KDM1A | |
| SCHEMBL2335893 | 0.81 | GPR119 (0.50) | GPR119 | |
| SCHEMBL14237295 | 0.81 | GPR119 (0.38) | GPR119CHRM2CHRM5CHRM1KDM1A | |
| SCHEMBL14237366 | 0.81 | GPR119 (0.36) | GPR119CHRM2CHRM5CHRM1KDM1A | |
| SCHEMBL2336445 | 0.78 | GPR119 (0.56) | GPR119KCNH2 | |
| SCHEMBL2337071 | 0.77 | GPR119 (0.47) | GPR119TRPV4KCNH2KDM1A | |
| SCHEMBL14237609 | 0.76 | GPR119 (0.40) | GPR119TRPV4CHRM2CHRM5CHRM1 | |
| SCHEMBL12391230 | 0.75 | GPR119 (0.65) | GPR119KCNH2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170864-B1 | PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2011-09-14 | — | — | EP | disclosed |