Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | GLA | P06280 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577867 | 0.86 | KDM4E (0.31) | KDM4EHPGDALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL30566587 | 0.85 | KDM4E (0.33) | TGFBR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL24577485 | 0.77 | TGFBR1 (0.42) | TGFBR1KDM4EMAPTHPGDALDH1A1 | |
| SCHEMBL29759692 | 0.77 | TGFBR1 (0.42) | TGFBR1KDM4EMAPTHPGDALDH1A1 | |
| SCHEMBL24577809 | 0.76 | TGFBR1 (0.43) | TGFBR1KDM4EMAPTHPGDALDH1A1 | |
| SCHEMBL24577223 | 0.75 | MAPT (0.40) | KDM4EMAPTHPGDALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL30566615 | 0.75 | TGFBR1 (0.42) | TGFBR1KDM4EMAPTHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL29759531 | 0.75 | TGFBR1 (0.42) | TGFBR1KDM4EMAPTHPGDALDH1A1 | |
| SCHEMBL29759559 | 0.75 | TGFBR1 (0.42) | TGFBR1KDM4EMAPTHPGDALDH1A1 | |
| SCHEMBL24577381 | 0.72 | ALDH1A1 (0.40) | KDM4EMAPTHPGDALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |