Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24579434 | 0.85 | ADRA1D (0.31) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24576409 | 0.80 | CSF1R (0.48) | MEN1KMT2AL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL24579545 | 0.71 | CSF1R (0.42) | — | |
| SCHEMBL24580449 | 0.71 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2GAACYP3A4 | |
| SCHEMBL24580297 | 0.69 | MAOA (0.33) | L3MBTL1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL24576230 | 0.64 | CSF1R (0.51) | — | |
| SCHEMBL2464563 | 0.63 | MEN1 (1.00) | MEN1KMT2AL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL986085 | 0.62 | MEN1 (0.52) | MEN1KMT2AL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL30951385 | 0.60 | MEN1 (0.46) | MEN1KMT2AL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL13998649 | 0.60 | ADRA1D (0.50) | MEN1KMT2AALDH1A1MAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140528-A1 | DEUTERATED COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS | GENZYME CORPORATION (US) | 2022-06-30 | — | — | WO | disclosed |