Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28032709 | 0.83 | ALDH1A1 (0.42) | ALDH1A1LMNAHSD17B10NPSR1GLO1 | |
| SCHEMBL1445319 | 0.81 | ALDH1A1 (0.40) | ALDH1A1LMNAHSD17B10NPSR1GLO1 | |
| SCHEMBL3569653 | 0.81 | ALDH1A1 (0.40) | ALDH1A1LMNAHSD17B10NPSR1GLO1 | |
| SCHEMBL12953137 | 0.81 | NPSR1 (0.48) | ALDH1A1LMNAHSD17B10NPSR1GLO1 | |
| SCHEMBL1763671 | 0.79 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10NPSR1GLO1 | |
| SCHEMBL11362082 | 0.79 | ALDH1A1 (0.39) | ALDH1A1LMNAHSD17B10NPSR1GLO1 | |
| SCHEMBL4330611 | 0.79 | ALDH1A1 (0.42) | ALDH1A1LMNAHSD17B10NPSR1GLO1 | |
| SCHEMBL28694144 | 0.79 | MAPT (0.41) | ALDH1A1LMNAHSD17B10NPSR1GLO1 | |
| SCHEMBL6674982 | 0.78 | ALDH1A1 (0.42) | ALDH1A1LMNAHSD17B10NPSR1GLO1 | |
| SCHEMBL1088298 | 0.78 | ALDH1A1 (0.42) | ALDH1A1LMNAHSD17B10NPSR1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4613745-A2 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | Gilead Sciences, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| US-12365666-B2 | Process for preparing a Cot inhibitor compound | GILEAD SCIENCES, INC. (US) | 2025-07-22 | — | — | US | disclosed |
| EP-4126862-B1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | GILEAD SCIENCES INC (US) | 2025-05-21 | — | — | EP | disclosed |
| CN-119390681-A | Process for preparing COT inhibitor compounds | 吉利德科学公司 | 2025-02-07 | — | — | CN | disclosed |
| CN-115397824-B | Process for preparing COT inhibitor compounds | 吉利德科学公司 | 2024-10-22 | — | — | CN | disclosed |
| US-20240199579-A1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | GILEAD SCIENCES, INC. | 2024-06-20 | — | — | US | disclosed |
| US-11845737-B2 | Process for preparing a Cot inhibitor compound | GILEAD SCIENCES, INC. (US) | 2023-12-19 | — | — | US | disclosed |
| US-20220380340-A1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | GILEAD SCIENCES, INC. | 2022-12-01 | — | — | US | disclosed |
| CN-115397824-A | Process for preparing COT inhibitor compounds | 吉利德科学公司 | 2022-11-25 | — | — | CN | disclosed |
| US-8026278-B2 | Inhibitors of pyruvate kinase as therapeutic agents for cancer | SMITH BRIAN R | 2011-09-27 | — | — | US | disclosed |
| EP-1891082-A4 | NOVEL INHIBITORS OF PYRUVATE KINASE AS THERAPEUTIC AGENTS FOR CANCER | LEYLAND JONES BRIAN (CA) | 2009-02-18 | — | — | EP | disclosed |
| US-20080311183-A1 | Novel Inhibitors of Pyruvate Kinase as Therapeutic Agents for Cancer | Leyland-Jones, Brian (CA) | 2008-12-18 | — | — | US | disclosed |
| EP-1891082-A1 | NOVEL INHIBITORS OF PYRUVATE KINASE AS THERAPEUTIC AGENTS FOR CANCER | Leyland-Jones, Brian (CA) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006125323-A1 | NOVEL INHIBITORS OF PYRUVATE KINASE AS THERAPEUTIC AGENTS FOR CANCER | DARWIN PHARMA INC (CA) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11845737-B2 | Process for preparing a Cot inhibitor compound | TPO, TFPI, TFPI2 | ALDH1A1 1859/4885LMNA 3342/4885HSD17B10 2539/4885 |
| US-20220380340-A1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | TPO, TFPI, TFPI2 | ALDH1A1 1859/4885LMNA 3342/4885HSD17B10 2539/4885 |
| US-20240199579-A1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | TPO, TFPI, TFPI2 | ALDH1A1 1859/4885LMNA 3342/4885HSD17B10 2539/4885 |
| US-20080311183-A1 | Novel Inhibitors of Pyruvate Kinase as Therapeutic Agents for Cancer | PDK2, PDK1, PDK3 | ALDH1A1 1161/4885LMNA 3405/4885HSD17B10 1514/4885 |
| US-12365666-B2 | Process for preparing a Cot inhibitor compound | TPO, TFPI, TFPI2 | ALDH1A1 1859/4885LMNA 3342/4885HSD17B10 2539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.