Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21626290 | 0.83 | ALDH1A1 (0.48) | USP2MAPK1ALDH1A1KDM4EMAPT | |
| SCHEMBL23957355 | 0.80 | MAPT (0.41) | USP2MAPK1ALDH1A1KDM4EMAPT | |
| SCHEMBL23379153 | 0.76 | USP2 (0.44) | USP2MAPK1ALDH1A1KDM4EMAPT | |
| SCHEMBL30888512 | 0.76 | NLRP3 (0.42) | USP2MAPK1ALDH1A1KDM4EMAPT | |
| SCHEMBL18499679 | 0.75 | ALDH1A1 (0.60) | USP2MAPK1ALDH1A1KDM4EMAPT | |
| SCHEMBL30625578 | 0.74 | ALDH1A1 (0.35) | USP2MAPK1ALDH1A1KDM4EMAPT | |
| SCHEMBL4294165 | 0.74 | LMNA (0.40) | USP2MAPK1ALDH1A1KDM4EMAPT | |
| SCHEMBL12819888 | 0.72 | KDM4E (0.41) | USP2MAPK1ALDH1A1KDM4EMAPT | |
| SCHEMBL12819825 | 0.72 | KDM4E (0.41) | USP2MAPK1ALDH1A1KDM4EMAPT | |
| SCHEMBL3321873 | 0.72 | ALDH1A1 (0.61) | USP2MAPK1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3445756-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2022-07-06 | — | — | EP | disclosed |