Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 8/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460016 | 0.84 | CCR2 (0.36) | TSHRENPP1POLBCCR2 | |
| SCHEMBL2460223 | 0.84 | ENPP1 (0.43) | ENPP1CCR2CCR5 | |
| SCHEMBL2455163 | 0.84 | ENPP1 (0.43) | TSHRENPP1POLBCCR2 | |
| SCHEMBL2457421 | 0.80 | ALKBH3 (0.36) | POLBCCR2CCR5 | |
| SCHEMBL2456947 | 0.80 | DAO (0.33) | ENPP1POLB | |
| SCHEMBL2459400 | 0.79 | NR3C1 (0.39) | TSHRCCR2CCR5 | |
| SCHEMBL2462976 | 0.76 | DAO (0.40) | ENPP1CCR2 | |
| SCHEMBL2464959 | 0.76 | ENPP1 (0.31) | ENPP1 | |
| SCHEMBL2462277 | 0.76 | ENPP1 (0.31) | ENPP1 | |
| SCHEMBL2457055 | 0.76 | AR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |