Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.80 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.80 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.80 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.80 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 3/20 | 0.58 |
| ▸ | MAOB | P27338 | 3/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1047500 | 0.90 | TAAR1 (0.89) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| SCHEMBL6314759 | 0.89 | TAAR1 (0.62) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| Phenethylamine SCHEMBL1330939 | 0.89 | — | — | |
| Phenethylamine SCHEMBL27634208 | 0.89 | HTR2A (1.00) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| Phenethylamine SCHEMBL1799333 | 0.89 | HTR2A (1.00) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| Phenethylamine SCHEMBL1332244 | 0.89 | — | — | |
| Phenethylamine SCHEMBL968 | 0.89 | — | — | |
| Phenethylamine SCHEMBL1331271 | 0.89 | — | — | |
| SCHEMBL20249530 | 0.88 | HTR2A (0.61) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| Phenethylamine SCHEMBL6241094 | 0.87 | HTR2A (0.94) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108218715-A | A kind of method for synthesizing α-phenyl-β-p-methylphenyl ethylamine | 江苏优嘉植物保护有限公司 | 2018-06-29 | — | — | CN | claimed |
| EP-0208948-A2 | A method for optical resolution of phenylacetic acid derivative | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1987-01-21 | — | — | EP | claimed |
| CN-108218715-A | A kind of method for synthesizing α-phenyl-β-p-methylphenyl ethylamine | 江苏优嘉植物保护有限公司 | 2018-06-29 | — | — | CN | disclosed |
| CN-108218715-A | A kind of method for synthesizing α-phenyl-β-p-methylphenyl ethylamine | 江苏优嘉植物保护有限公司 | 2018-06-29 | — | — | CN | disclosed |
| US-20160257677-A1 | LARGE SUBSTITUTENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2016-09-08 | — | — | US | disclosed |
| US-9156821-B2 | Large substituent, non-phenolic opioids and methods of use thereof | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2015-10-13 | — | — | US | disclosed |
| US-20150051194-A1 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2015-02-19 | — | — | US | disclosed |
| US-8901148-B2 | Large substituent, non-phenolic opioids and methods of use thereof | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2014-12-02 | — | — | US | disclosed |
| EP-1924559-B1 | 8-CARBOXAMIDO-SUBSTITUTED-2 , 6-METHANO-3-BENZAZOCINES AND 3 - CARBOXAMIDO- SUBSTITUTED MORPHANES AS OPIOID RECEPTOR BINDING AGENTS | RENSSELAER POLYTECH INST (US) | 2014-04-16 | — | — | EP | disclosed |
| US-20130345251-A1 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2013-12-26 | — | — | US | disclosed |
| US-8541586-B2 | Large substituent, non-phenolic opioids and methods of use thereof | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2013-09-24 | — | — | US | disclosed |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| WO-2007014137-A2 | 8-CARBOXAMIDO-SUBSTITUTED-2 , 6-METHANO-3-BENZAZOCINES AND 3 - CARBOXAMIDO- SUBSTITUTED MORPHANES AS OPIOID RECEPTOR BINDING AGENTS | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2007-02-01 | — | — | WO | disclosed |
| US-20070021457-A1 | analgesics, antidiarrheal agents, anticonvulsants, antitussives, anti-addiction; 8-Substituted-2,6-methano-3-benzazocines | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2007-01-25 | — | — | US | disclosed |
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | HAMANAKA ERNEST S | 2006-10-12 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
| US-5232946-A | Promoting weight gain and reduction of blood sugar and fat deposits in animals, feed efficiency | DR. KARL THOMAE GMBH (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0400011-A1 | NEW PHENYLETHANOLAMINES. | BOEHRINGER INGELHEIM VETMED (DE) | 1990-12-05 | — | — | EP | disclosed |
| EP-0375791-A1 | Phenyl ethanol amines, their use as pharmaceutical compounds and as performance stimulants in animals, as well as processes for their preparation | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 1990-07-04 | — | — | EP | disclosed |
| WO-1990006299-A1 | NEW PHENYLETHANOLAMINES | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 1990-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARA, PPARG, PPARD | HTR2A 1889/4885CYP2A6 836/4885SMN1; SMN2 3271/4885 |
| US-20130345251-A1 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | OPRK1, OPRM1, OPRD1 | HTR2A 61/4885CYP2A6 47/4885SMN1; SMN2 1703/4885 |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | HTR2A 1759/4885CYP2A6 976/4885SMN1; SMN2 3404/4885 |
| US-20070021457-A1 | analgesics, antidiarrheal agents, anticonvulsants, antitussives, anti-addiction; 8-Substituted-2,6-methano-3-benzazocines | OPRM1, OPRK1, OPRL1 | HTR2A 43/4885CYP2A6 25/4885SMN1; SMN2 2384/4885 |
| US-20150051194-A1 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | OPRK1, OPRM1, OPRD1 | HTR2A 61/4885CYP2A6 47/4885SMN1; SMN2 1703/4885 |
| US-20160257677-A1 | LARGE SUBSTITUTENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF | OPRM1, OPRK1, SIGMAR1 | HTR2A 111/4885CYP2A6 59/4885SMN1; SMN2 1933/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | HTR2A 1759/4885CYP2A6 976/4885SMN1; SMN2 3404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.