Sugi Predict

Sugi Predict / Compounds / SCHEMBL2459558

SCHEMBL2459558

SCHEMBL2459558

Cl[N+]12C=CN=CC1=C(C1CCOC1)N=C2c1cccc(OCc2ccccc2)c1

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ PRKDC P78527 1/20 0.35
▸ ATM Q13315 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.34
▸ IGF1R P08069 8/20 0.34
▸ NR1H2 P55055 1/20 0.33
▸ PDE10A Q9Y233 1/20 0.33
▸ JAK2 O60674 1/20 0.33
▸ JAK1 P23458 1/20 0.33
▸ SLC16A3 O15427 1/20 0.33
▸ SLC16A1 P53985 1/20 0.33
▸ MCTS1 Q9ULC4 1/20 0.33
▸ CHRNB2 P17787 1/20 0.33
▸ CHRNB4 P30926 1/20 0.33
▸ CHRNA3 P32297 1/20 0.33
▸ CHRNA7 P36544 1/20 0.33
▸ CHRNA4 P43681 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2460683 0.89 IGF1R (0.36) PRKDCATMIGF1RPDE10A
SCHEMBL2463346 0.86 IGF1R (0.35) IGF1RNR1H2PDE10AJAK2JAK1
SCHEMBL2459990 0.85 IGF1R (0.39) IGF1RNR1H2PDE10AJAK2JAK1
SCHEMBL2459426 0.85 BRD4 (0.36) PRKDCATMALDH1A1NR1H2PDE10A
SCHEMBL2460207 0.85 NR1H2 (0.35) IGF1RNR1H2PDE10AJAK2JAK1
SCHEMBL2463487 0.85 PRMT5 (0.38) ALDH1A1IGF1RCHRNB2CHRNB4CHRNA3
SCHEMBL2460301 0.85 IGF1R (0.35) IGF1RNR1H2PDE10AJAK2JAK1
SCHEMBL2460369 0.84 IGF1R (0.38) IGF1RNR1H2PDE10A
SCHEMBL2465897 0.84 F9 (0.34) IGF1RNR1H2PDE10A
SCHEMBL2464664 0.83 CYP4F2 (0.34) IGF1RNR1H2PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
EP-1675860-A2 IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2006-07-05 — — EP disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed
WO-2005037836-A2 IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 PRKDC 271/4885ATM 427/4885ALDH1A1 703/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 PRKDC 271/4885ATM 427/4885ALDH1A1 703/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 PRKDC 271/4885ATM 427/4885ALDH1A1 703/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.