Sugi Predict

Sugi Predict / Compounds / SCHEMBL2459990

SCHEMBL2459990

SCHEMBL2459990

OCC1CCC(C2=C3C=NC=C[N+]3(Cl)C(c3cccc(OCc4ccccc4)c3)=N2)CC1

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 10/20 0.39
▸ SPHK2 Q9NRA0 3/20 0.37
▸ SPHK1 Q9NYA1 3/20 0.37
▸ PLAT P00750 1/20 0.36
▸ CYP4F2 P78329 1/20 0.34
▸ CYP4A11 Q02928 1/20 0.34
▸ TNK2 Q07912 1/20 0.34
▸ NR1H2 P55055 1/20 0.34
▸ PDE10A Q9Y233 1/20 0.34
▸ JAK2 O60674 1/20 0.34
▸ JAK1 P23458 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2460369 0.92 IGF1R (0.38) IGF1RSPHK2SPHK1PLATCYP4F2
SCHEMBL2460257 0.90 IGF1R (0.40) IGF1RSPHK2SPHK1PLATCYP4F2
SCHEMBL2460301 0.89 IGF1R (0.35) IGF1RNR1H2PDE10AJAK2JAK1
SCHEMBL2463487 0.87 PRMT5 (0.38) IGF1RSPHK2SPHK1
SCHEMBL2463346 0.87 IGF1R (0.35) IGF1RCYP4F2CYP4A11TNK2NR1H2
SCHEMBL2460497 0.86 JAK2 (0.40) IGF1RJAK2JAK1
SCHEMBL2460207 0.86 NR1H2 (0.35) IGF1RCYP4F2CYP4A11TNK2NR1H2
SCHEMBL2459426 0.86 BRD4 (0.36) PLATNR1H2PDE10AJAK2JAK1
SCHEMBL2464664 0.85 CYP4F2 (0.34) IGF1RSPHK2SPHK1CYP4F2CYP4A11
SCHEMBL2459558 0.85 PRKDC (0.35) IGF1RNR1H2PDE10AJAK2JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
EP-1675860-A2 IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2006-07-05 — — EP disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed
WO-2005037836-A2 IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 IGF1R 1/4885SPHK2 2823/4885SPHK1 2897/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885SPHK2 2823/4885SPHK1 2897/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885SPHK2 2823/4885SPHK1 2897/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.