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SCHEMBL2464664

SCHEMBL2464664

OCC1(O)CC(C2=C3C=NC=C[N+]3(Cl)C(c3cccc(OCc4ccccc4)c3)=N2)C1

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ CYP4F2 P78329 1/20 0.34
▸ CYP4A11 Q02928 1/20 0.34
▸ NR1H2 P55055 1/20 0.33
▸ PDE10A Q9Y233 1/20 0.33
▸ SPHK2 Q9NRA0 2/20 0.33
▸ SPHK1 Q9NYA1 2/20 0.33
▸ BACE1 P56817 1/20 0.33
▸ MRGPRX4 Q96LA9 1/20 0.33
▸ FAAH O00519 1/20 0.33
▸ CNR2 P34972 1/20 0.33
▸ IGF1R P08069 5/20 0.32
▸ TNK2 Q07912 1/20 0.32
▸ F9 P00740 1/20 0.32
▸ F10 P00742 1/20 0.32
▸ HDAC4 P56524 1/20 0.32
▸ NAAA Q02083 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2459447 0.92 PDE10A (0.33) NR1H2PDE10AMRGPRX4FAAHCNR2
SCHEMBL2465897 0.91 F9 (0.34) NR1H2PDE10AMRGPRX4FAAHCNR2
SCHEMBL2464620 0.90 BTK (0.32) NR1H2PDE10AMRGPRX4FAAHCNR2
SCHEMBL2457285 0.90 IGF1R (0.35) CYP4F2CYP4A11PDE10ABACE1MRGPRX4
SCHEMBL2460369 0.86 IGF1R (0.38) CYP4F2CYP4A11NR1H2PDE10ASPHK2
SCHEMBL2463346 0.86 IGF1R (0.35) CYP4F2CYP4A11NR1H2PDE10AMRGPRX4
SCHEMBL2459990 0.85 IGF1R (0.39) CYP4F2CYP4A11NR1H2PDE10ASPHK2
SCHEMBL2460207 0.85 NR1H2 (0.35) CYP4F2CYP4A11NR1H2PDE10AMRGPRX4
SCHEMBL2459426 0.85 BRD4 (0.36) NR1H2PDE10AMRGPRX4HDAC4
SCHEMBL2459558 0.83 PRKDC (0.35) NR1H2PDE10AIGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
EP-1675860-A2 IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2006-07-05 — — EP disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed
WO-2005037836-A2 IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 CYP4F2 1114/4885CYP4A11 1904/4885NR1H2 2603/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 CYP4F2 1114/4885CYP4A11 1904/4885NR1H2 2603/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 CYP4F2 1114/4885CYP4A11 1904/4885NR1H2 2603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.