Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17584792 | 0.87 | LTA4H (0.41) | TLR8LTA4HNR5A1NPC1RAB9A | |
| SCHEMBL11304283 | 0.84 | MEN1 (0.35) | TLR8NOS2CYP1A2NPC1RAB9A | |
| SCHEMBL2459962 | 0.83 | TLR7 (0.36) | TLR7 | |
| SCHEMBL30657772 | 0.77 | LTA4H (0.38) | TLR8LTA4HCYP1A2NPC1RAB9A | |
| SCHEMBL19295640 | 0.76 | RAB9A (0.47) | MCHR1TLR8NOS2LTA4HNR5A1 | |
| SCHEMBL11796953 | 0.75 | NR5A1 (0.42) | LTA4HNR5A1MEN1MAPTKMT2A | |
| SCHEMBL17585439 | 0.75 | TLR7 (0.41) | MCHR1TLR8TLR7CYP3A4ADORA2A | |
| SCHEMBL598441 | 0.74 | CYP2D6 (0.43) | MCHR1TLR8LTA4HCYP1A2CYP2C9 | |
| SCHEMBL17585442 | 0.74 | LTA4H (0.40) | LTA4HNR5A1NPC1RAB9AMAPT | |
| SCHEMBL808604 | 0.74 | CDK1 (0.47) | MCHR1TLR8CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848375-B1 | METHODS OF PREPARING INTERMEDIATES FOR TOLL-LIKE RECEPTOR MODULATORS | GILEAD SCIENCES INC (US) | 2023-12-27 | — | — | EP | disclosed |
| CN-115043840-A | Methods for preparing TOLL-like receptor modulators | 吉利德科学公司 | 2022-09-13 | — | — | CN | disclosed |
| CN-107074860-B | Methods for preparing TOLL-like receptor modulators | 吉利德科学公司 | 2022-07-15 | — | — | CN | disclosed |
| US-11110091-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2021-09-07 | — | — | US | disclosed |
| US-11110091-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2021-09-07 | — | — | US | disclosed |
| EP-3848375-A1 | METHODS OF PREPARING INTERMEDIATES FOR TOLL-LIKE RECEPTOR MODULATORS | Gilead Sciences, Inc. (US) | 2021-07-14 | — | — | EP | disclosed |
| EP-3461828-B1 | METHODS OF PREPARING TOLL-LIKE RECEPTOR MODULATORS | GILEAD SCIENCES INC (US) | 2020-11-25 | — | — | EP | disclosed |
| US-20190321366-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2019-10-24 | — | — | US | disclosed |
| US-20190321366-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2019-10-24 | — | — | US | disclosed |
| EP-3461828-A2 | METHODS OF PREPARING TOLL-LIKE RECEPTOR MODULATORS | GILEAD SCIENCES, INC. (US) | 2019-04-03 | — | — | EP | disclosed |
| US-8367670-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-8367670-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-8367670-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| CN-102272134-A | Toll-like receptor modulators | — | 2011-12-07 | — | — | CN | disclosed |
| EP-2364314-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | Gilead Sciences, Inc. (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010077613-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077613-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| US-20100143301-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100143301-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100143301-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100143301-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | TLR3, TLR2, TLR6 | MCHR1 1938/4885TLR8 8/4885NOS2 1188/4885 |
| US-11110091-B2 | Modulators of toll-like receptors | TLR3, TLR2, TLR6 | MCHR1 1938/4885TLR8 8/4885NOS2 1188/4885 |
| US-20190321366-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | TLR3, TLR2, TLR6 | MCHR1 1938/4885TLR8 8/4885NOS2 1188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.