Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29718735 | 0.85 | CXCL8 (0.58) | L3MBTL1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3135922 | 0.85 | CXCL8 (0.58) | L3MBTL1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22442181 | 0.84 | L3MBTL1 (0.50) | L3MBTL1HTTSMN1; SMN2POLBNPSR1 | |
| SCHEMBL29718486 | 0.80 | L3MBTL1 (0.43) | L3MBTL1ALKBH1CXCL8HTTSMN1; SMN2 | |
| SCHEMBL20777752 | 0.80 | KCNJ5 (0.44) | L3MBTL1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL597834 | 0.78 | L3MBTL1 (0.69) | L3MBTL1HTTSMN1; SMN2POLBNPSR1 | |
| SCHEMBL22994473 | 0.77 | HPGD (0.45) | L3MBTL1HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7196858 | 0.76 | MAPT (0.61) | L3MBTL1SMN1; SMN2KMT2AMEN1TDP1 | |
| SCHEMBL3205239 | 0.75 | L3MBTL1 (0.55) | L3MBTL1HTTPOLBNPSR1KMT2A | |
| SCHEMBL909198 | 0.75 | TBXAS1 (0.48) | L3MBTL1SMN1; SMN2POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213108-A1 | DEAZAGUAINE COMPOUNDS AS JAK2 V617F INHIBITORS | INCYTE CORPORATION | 2022-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213108-A1 | DEAZAGUAINE COMPOUNDS AS JAK2 V617F INHIBITORS | JAK2, JAK1, VHL | L3MBTL1 763/4885PDE4A 852/4885PDE4B 1306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.