Sugi Predict

Sugi Predict / Compounds / SCHEMBL2460646

SCHEMBL2460646

SCHEMBL2460646

C1=CC(C2=C3C=NC=C[N+]3(Nc3ccccc3)C(c3cccc(OCc4ccccc4)c3)=N2)=C1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR1H4 Q96RI1 2/20 0.37
▸ MRGPRX4 Q96LA9 1/20 0.34
▸ FFAR1 O14842 1/20 0.33
▸ DYRK1B Q9Y463 1/20 0.33
▸ BCHE P06276 1/20 0.33
▸ SYK P43405 1/20 0.33
▸ NR1H2 P55055 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ NR4A2 P43354 2/20 0.32
▸ PDK1 Q15118 1/20 0.32
▸ PDK2 Q15119 1/20 0.32
▸ PDK3 Q15120 1/20 0.32
▸ PDK4 Q16654 1/20 0.32
▸ CTSV O60911 1/20 0.32
▸ CTSL P07711 1/20 0.32
▸ SGMS2 Q8NHU3 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ GAA P10253 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2464139 0.90 NR1H2 (0.35) NR1H4MRGPRX4DYRK1BBCHENR1H2
SCHEMBL2463246 0.90 BCHE (0.37) NR1H4MRGPRX4BCHENR1H2MAPK1
SCHEMBL2463512 0.86 BCHE (0.33) NR1H4MRGPRX4BCHENR1H2MAPK1
SCHEMBL2462748 0.86 IGF1R (0.33) NR1H4MRGPRX4MAPK1
SCHEMBL2457126 0.86 GAA (0.33) NR1H4MRGPRX4DYRK1BBCHENR1H2
SCHEMBL2460200 0.84 MAOB (0.37) NR1H4MRGPRX4NR1H2NR4A2MAOB
SCHEMBL2458350 0.84 MRGPRX4 (0.38) NR1H4MRGPRX4NR1H2MAPK1NR4A2
SCHEMBL2460741 0.81 SMPD1 (0.36) MRGPRX4NR1H2NR4A2MAOB
SCHEMBL2463035 0.81 BCHE (0.37) NR1H4MRGPRX4BCHENR1H2NR4A2
SCHEMBL2457047 0.81 MAOB (0.34) NR1H4MRGPRX4NR1H2NR4A2MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 NR1H4 3507/4885MRGPRX4 1767/4885FFAR1 742/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 NR1H4 3507/4885MRGPRX4 1767/4885FFAR1 742/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 NR1H4 3507/4885MRGPRX4 1767/4885FFAR1 742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.