Sugi Predict

Sugi Predict / Compounds / SCHEMBL2462748

SCHEMBL2462748

SCHEMBL2462748

C1=CC(C2=C3C=NC=C[N+]3(NCC3CC3)C(c3cccc(OCc4ccccc4)c3)=N2)=C1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 5/20 0.33
▸ PDE10A Q9Y233 1/20 0.32
▸ JAK2 O60674 1/20 0.32
▸ JAK1 P23458 1/20 0.32
▸ CHRNB2 P17787 3/20 0.32
▸ CHRNB4 P30926 3/20 0.32
▸ CHRNA3 P32297 3/20 0.32
▸ CHRNA7 P36544 3/20 0.32
▸ CHRNA4 P43681 3/20 0.32
▸ MRGPRX4 Q96LA9 1/20 0.32
▸ LMNA P02545 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ ALOX15 P16050 1/20 0.31
▸ TSHR P16473 1/20 0.31
▸ MAPK1 P28482 1/20 0.31
▸ HTT P42858 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ NR1H4 Q96RI1 1/20 0.31
▸ ALOX5 P09917 1/20 0.31
▸ HDAC4 P56524 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2463246 0.89 BCHE (0.37) MRGPRX4LMNAHPGDALOX15TSHR
SCHEMBL2464139 0.87 NR1H2 (0.35) MRGPRX4LMNAHPGDALOX15TSHR
SCHEMBL2463512 0.86 BCHE (0.33) PDE10AJAK2MRGPRX4LMNAHPGD
SCHEMBL2460646 0.86 NR1H4 (0.37) MRGPRX4MAPK1NR1H4
SCHEMBL2457126 0.85 GAA (0.33) JAK2MRGPRX4LMNAMAPK1NR1H4
SCHEMBL2460200 0.81 MAOB (0.37) IGF1RMRGPRX4NR1H4
SCHEMBL2458350 0.80 MRGPRX4 (0.38) MRGPRX4LMNAHPGDALOX15TSHR
SCHEMBL2460741 0.78 SMPD1 (0.36) IGF1RMRGPRX4ALOX5HDAC4NAAA
SCHEMBL2463035 0.77 BCHE (0.37) MRGPRX4NR1H4
SCHEMBL2457047 0.77 MAOB (0.34) IGF1RMRGPRX4NR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 IGF1R 1/4885PDE10A 2449/4885JAK2 9/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885PDE10A 2449/4885JAK2 9/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885PDE10A 2449/4885JAK2 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.