Sugi Predict

Sugi Predict / Compounds / SCHEMBL2463246

SCHEMBL2463246

SCHEMBL2463246

C1=CC(C2=C3C=NC=C[N+]3(NCc3ccccc3)C(c3cccc(OCc4ccccc4)c3)=N2)=C1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BCHE P06276 3/20 0.37
▸ MRGPRX4 Q96LA9 1/20 0.34
▸ NR1H4 Q96RI1 1/20 0.33
▸ NR1H2 P55055 1/20 0.33
▸ MEN1 O00255 2/20 0.32
▸ ALDH1A1 P00352 2/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ MAPK1 P28482 2/20 0.32
▸ SPHK2 Q9NRA0 1/20 0.32
▸ SPHK1 Q9NYA1 1/20 0.32
▸ NR4A2 P43354 2/20 0.32
▸ L3MBTL1 Q9Y468 2/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ GAA P10253 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ THRB P10828 1/20 0.32
▸ PKM P14618 1/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ BLM P54132 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2464139 0.90 NR1H2 (0.35) BCHEMRGPRX4NR1H4NR1H2MAPK1
SCHEMBL2463512 0.90 BCHE (0.33) BCHEMRGPRX4NR1H4NR1H2ALDH1A1
SCHEMBL2460646 0.90 NR1H4 (0.37) BCHEMRGPRX4NR1H4NR1H2MEN1
SCHEMBL2457126 0.89 GAA (0.33) BCHEMRGPRX4NR1H4NR1H2MEN1
SCHEMBL2462748 0.89 IGF1R (0.33) MRGPRX4NR1H4MAPK1LMNAHPGD
SCHEMBL2460200 0.84 MAOB (0.37) MRGPRX4NR1H4NR1H2NR4A2MAOB
SCHEMBL2458350 0.84 MRGPRX4 (0.38) MRGPRX4NR1H4NR1H2MAPK1NR4A2
SCHEMBL2460741 0.81 SMPD1 (0.36) MRGPRX4NR1H2NR4A2MAOB
SCHEMBL2463035 0.81 BCHE (0.37) BCHEMRGPRX4NR1H4NR1H2NR4A2
SCHEMBL2457047 0.81 MAOB (0.34) MRGPRX4NR1H4NR1H2SPHK2NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 BCHE 4603/4885MRGPRX4 1767/4885NR1H4 3507/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 BCHE 4603/4885MRGPRX4 1767/4885NR1H4 3507/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 BCHE 4603/4885MRGPRX4 1767/4885NR1H4 3507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.