Sugi Predict

Sugi Predict / Compounds / SCHEMBL2463512

SCHEMBL2463512

SCHEMBL2463512

C=CCN[N+]12C=CN=CC1=C(C1=CC=C1)N=C2c1cccc(OCc2ccccc2)c1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BCHE P06276 5/20 0.33
▸ MRGPRX4 Q96LA9 1/20 0.32
▸ NR1H4 Q96RI1 1/20 0.32
▸ ERN1 O75460 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.31
▸ NPC1 O15118 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ RAB9A P51151 1/20 0.31
▸ JAK2 O60674 1/20 0.31
▸ JAK3 P52333 1/20 0.31
▸ PDE10A Q9Y233 1/20 0.31
▸ NR1H2 P55055 1/20 0.31
▸ NR4A2 P43354 2/20 0.30
▸ MAOA P21397 1/20 0.30
▸ MAOB P27338 1/20 0.30
▸ LMNA P02545 1/20 0.30
▸ HPGD P15428 1/20 0.30
▸ ALOX15 P16050 1/20 0.30
▸ TSHR P16473 1/20 0.30
▸ MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2463246 0.90 BCHE (0.37) BCHEMRGPRX4NR1H4KDM4EALDH1A1
SCHEMBL2464139 0.87 NR1H2 (0.35) BCHEMRGPRX4NR1H4ERN1NR1H2
SCHEMBL2460646 0.86 NR1H4 (0.37) BCHEMRGPRX4NR1H4KDM4EALDH1A1
SCHEMBL2457126 0.86 GAA (0.33) BCHEMRGPRX4NR1H4ERN1KDM4E
SCHEMBL2462748 0.86 IGF1R (0.33) MRGPRX4NR1H4JAK2PDE10ALMNA
SCHEMBL2460200 0.82 MAOB (0.37) MRGPRX4NR1H4NR1H2NR4A2MAOB
SCHEMBL2458350 0.81 MRGPRX4 (0.38) MRGPRX4NR1H4NR1H2NR4A2MAOB
SCHEMBL2460741 0.78 SMPD1 (0.36) MRGPRX4NR1H2NR4A2MAOB
SCHEMBL2463035 0.78 BCHE (0.37) BCHEMRGPRX4NR1H4NR1H2NR4A2
SCHEMBL2457047 0.78 MAOB (0.34) MRGPRX4NR1H4NR1H2NR4A2MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 BCHE 4603/4885MRGPRX4 1767/4885NR1H4 3507/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 BCHE 4603/4885MRGPRX4 1767/4885NR1H4 3507/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 BCHE 4603/4885MRGPRX4 1767/4885NR1H4 3507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.