Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | AGXT | P21549 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 3/20 | 0.32 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27708670 | 0.69 | CHRNA1 (0.35) | MEN1KMT2AGABRG2GABRB3GABRA5 | |
| SCHEMBL27286322 | 0.66 | ALDH1A1 (0.33) | — | |
| SCHEMBL27589212 | 0.66 | MAOA (0.38) | MAOBIDO1KDM1A | |
| SCHEMBL28746800 | 0.65 | ALDH1A1 (0.32) | — | |
| SCHEMBL946696 | 0.64 | BACE1 (0.46) | NPSR1MAOBAPPTAAR1IDO1 | |
| SCHEMBL4717 | 0.59 | CALM1 (0.57) | MAOBTAAR1IDO1AGXTKDM1A | |
| SCHEMBL9660784 | 0.59 | TAAR1 (0.65) | MAOBTAAR1IDO1AGXTKDM1A | |
| SCHEMBL31499406 | 0.59 | CALM1 (0.57) | MAOBTAAR1IDO1AGXTKDM1A | |
| SCHEMBL4795297 | 0.58 | MAOA (0.40) | MAOBIDO1AGXTKDM1A | |
| SCHEMBL28239960 | 0.58 | ALDH1A1 (0.44) | TAAR1IDO1AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365748-A1 | IMIDAZOISOINDOLE NEUROPEPTIDE S RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2011-09-21 | — | — | EP | claimed |
| WO-2010056567-A1 | IMIDAZOISOINDOLE NEUROPEPTIDE S RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-05-20 | — | — | WO | claimed |