Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22743951 | 0.77 | ALDH1A1 (0.42) | LMNARXFP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL31123821 | 0.77 | ALDH1A1 (0.42) | LMNARXFP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL4433755 | 0.74 | LMNA (0.44) | LMNARXFP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL247143 | 0.72 | — | — | |
| SCHEMBL248918 | 0.71 | NPSR1 (0.35) | LMNAMAPTKMT2APOLBKDM4E | |
| SCHEMBL4437069 | 0.71 | PDE10A (0.47) | LMNARXFP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL22743020 | 0.71 | MAPT (0.45) | LMNAL3MBTL1ALDH1A1MAPTMEN1 | |
| SCHEMBL246127 | 0.67 | HSD17B10 (0.45) | LMNARXFP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL14293899 | 0.66 | HSD17B10 (0.50) | L3MBTL1ALDH1A1MAPTPKMMEN1 | |
| SCHEMBL17261503 | 0.66 | PKM (0.55) | LMNARXFP1L3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003262-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |