Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.39 |
| ▸ | JAK2 | O60674 | 7/20 | 0.39 |
| ▸ | TYK2 | P29597 | 7/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 5/20 | 0.36 |
| ▸ | RET | P07949 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24615598 | 0.90 | JAK1 (0.42) | JAK1JAK2TYK2JAK3RET | |
| SCHEMBL24615408 | 0.84 | TYK2 (0.42) | JAK1JAK2TYK2JAK3KCNH2 | |
| SCHEMBL24615298 | 0.82 | JAK2 (0.40) | JAK1JAK2TYK2JAK3RET | |
| SCHEMBL29772862 | 0.82 | JAK1 (0.44) | JAK1JAK2TYK2JAK3RET | |
| SCHEMBL24615583 | 0.82 | JAK1 (0.44) | JAK1JAK2TYK2JAK3RET | |
| SCHEMBL24615602 | 0.82 | JAK2 (0.38) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL24615424 | 0.81 | TYK2 (0.41) | JAK1JAK2TYK2JAK3RET | |
| SCHEMBL24615433 | 0.81 | JAK2 (0.49) | JAK1JAK2TYK2JAK3RET | |
| SCHEMBL24615410 | 0.80 | TYK2 (0.45) | JAK1JAK2TYK2JAK3KCNH2 | |
| SCHEMBL24615600 | 0.80 | JAK1 (0.40) | JAK1JAK2TYK2JAK3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |