Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30656545 | 1.00 | ROCK2 (0.47) | ROCK2ROCK1EGLN1YTHDC1HSP90AB1 | |
| SCHEMBL29779044 | 0.85 | HSP90AB1 (0.57) | ROCK2ROCK1EGLN1YTHDC1HSP90AB1 | |
| SCHEMBL24616910 | 0.85 | HSP90AB1 (0.57) | ROCK2ROCK1EGLN1YTHDC1HSP90AB1 | |
| SCHEMBL24616951 | 0.85 | ROCK2 (0.47) | ROCK2ROCK1EGLN1YTHDC1MAPK1 | |
| SCHEMBL24616949 | 0.84 | ROCK2 (0.43) | ROCK2ROCK1EGLN1YTHDC1MAPK1 | |
| SCHEMBL24617245 | 0.84 | ROCK2 (0.42) | ROCK2ROCK1EGLN1YTHDC1HSP90AB1 | |
| SCHEMBL29778420 | 0.84 | WNT1 (0.51) | ROCK2ROCK1EGLN1YTHDC1GRM2 | |
| SCHEMBL29778991 | 0.84 | ROCK2 (0.55) | ROCK2ROCK1EGLN1YTHDC1MAPK1 | |
| SCHEMBL24616901 | 0.84 | ROCK2 (0.55) | ROCK2ROCK1EGLN1YTHDC1MAPK1 | |
| SCHEMBL29135953 | 0.84 | WNT1 (0.51) | ROCK2ROCK1EGLN1YTHDC1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |