Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 4/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.51 |
| ▸ | CCNC | P24863 | 2/20 | 0.47 |
| ▸ | CDK8 | P49336 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | FSCN1 | Q16658 | 3/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | HAT1 | O14929 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778420 | 1.00 | WNT1 (0.51) | WNT1GSK3BDYRK1ACCNCCDK8 | |
| SCHEMBL24616951 | 0.85 | ROCK2 (0.47) | ROCK2ROCK1EGLN1GRM2YTHDC1 | |
| SCHEMBL29778991 | 0.84 | ROCK2 (0.55) | ROCK2ROCK1EGLN1GRM2YTHDC1 | |
| SCHEMBL24616956 | 0.84 | MAP1LC3B (0.47) | ROCK2ROCK1EGLN1GRM2YTHDC1 | |
| SCHEMBL30656545 | 0.84 | ROCK2 (0.47) | CDK8ROCK2ROCK1EGLN1GRM2 | |
| SCHEMBL24617447 | 0.84 | ROCK2 (0.45) | WNT1GSK3BDYRK1AROCK2ROCK1 | |
| SCHEMBL24616943 | 0.84 | ROCK2 (0.47) | CDK8ROCK2ROCK1EGLN1GRM2 | |
| SCHEMBL24616901 | 0.84 | ROCK2 (0.55) | ROCK2ROCK1EGLN1GRM2YTHDC1 | |
| SCHEMBL24616900 | 0.83 | ROCK2 (0.46) | CDK8ROCK2ROCK1EGLN1GRM2 | |
| SCHEMBL24617452 | 0.82 | ROCK1 (0.45) | ROCK2ROCK1EGLN1GRM2YTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |