Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.58 |
| ▸ | PIM1 | P11309 | 8/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.58 |
| ▸ | JAK2 | O60674 | 3/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | PAK4 | O96013 | 1/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.54 |
| ▸ | CLK2 | P49760 | 4/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.54 |
| ▸ | CLK1 | P49759 | 2/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.54 |
| ▸ | CLK3 | P49761 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 3/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460632 | 0.87 | FGFR1 (0.54) | GSK3BPIM1ROCK2AURKBJAK2 | |
| SCHEMBL2458511 | 0.79 | NPC1 (0.50) | CDK5DYRK1ADYRK1BDYRK3CDK5R1 | |
| SCHEMBL2457606 | 0.77 | GSK3B (0.58) | GSK3BPIM1ROCK2AURKBJAK2 | |
| SCHEMBL2461143 | 0.73 | GSK3B (0.53) | GSK3BPIM1ROCK2AURKBJAK2 | |
| SCHEMBL2457760 | 0.73 | GSK3B (0.66) | GSK3BPIM1ROCK2AURKBJAK2 | |
| SCHEMBL2459978 | 0.72 | GSK3B (0.60) | GSK3BPIM1ROCK2AURKBJAK2 | |
| SCHEMBL2461778 | 0.72 | GSK3B (0.59) | GSK3BPIM1ROCK2AURKBJAK2 | |
| SCHEMBL2459152 | 0.72 | BRD4 (0.50) | DYRK1BLCKCDK8BTKMAPK1 | |
| SCHEMBL3799521 | 0.71 | CLK1 (0.61) | GSK3BPIM1ROCK2AURKBJAK2 | |
| SCHEMBL2455150 | 0.71 | KDM4E (0.41) | ACVR1KDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, MET | GSK3B 817/4885PIM1 1476/4885ROCK2 1181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.