Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.60 |
| ▸ | CLK1 | P49759 | 2/20 | 0.60 |
| ▸ | CLK2 | P49760 | 2/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.60 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.60 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.60 |
| ▸ | CLK3 | P49761 | 1/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.60 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.51 |
| ▸ | PIM1 | P11309 | 4/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 9/20 | 0.49 |
| ▸ | NOS1 | P29475 | 3/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460037 | 0.87 | FGFR1 (0.60) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL2461478 | 0.77 | GSK3B (0.60) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL2463728 | 0.77 | NPC1 (0.54) | CLK1DYRK1ADYRK1BDYRK2LRRK2 | |
| SCHEMBL2455100 | 0.75 | GSK3B (1.00) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL16740690 | 0.74 | NOS1 (0.72) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL16573980 | 0.74 | GSK3B (0.71) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL27663173 | 0.74 | FGFR1 (0.74) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL4791316 | 0.74 | CLK1 (1.00) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL2457760 | 0.74 | GSK3B (0.66) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL27537145 | 0.72 | GSK3B (0.64) | GSK3BCLK1CLK2CDK5DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-09-29 | — | — | US | disclosed |
| WO-2010068287-A2 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, MET | GSK3B 817/4885CLK1 3871/4885CLK2 3759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.