Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22588766 | 0.89 | MAPT (0.46) | PKMALDH1A1POLBHPGDL3MBTL1 | |
| SCHEMBL24620583 | 0.85 | RAB9A (0.47) | MEN1KMT2AHSD17B10PKMALDH1A1 | |
| SCHEMBL24620710 | 0.84 | ALDH1A1 (0.48) | PKMALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL24620546 | 0.83 | HPGDS (0.50) | MEN1KMT2AHSD17B10PKMALDH1A1 | |
| SCHEMBL22588751 | 0.82 | GAA (0.60) | MEN1KMT2AHSD17B10ALDH1A1RAB9A | |
| SCHEMBL22600513 | 0.82 | PKM (0.42) | MEN1KMT2AHSD17B10PKMALDH1A1 | |
| SCHEMBL29808369 | 0.82 | GAA (0.60) | MEN1KMT2AHSD17B10ALDH1A1RAB9A | |
| SCHEMBL21875128 | 0.82 | KLKB1 (0.58) | MEN1KMT2AHSD17B10PKMALDH1A1 | |
| SCHEMBL24620725 | 0.82 | GRM4 (0.46) | ALDH1A1L3MBTL1GRM4KLKB1LMNA | |
| SCHEMBL29808328 | 0.82 | GRM4 (0.46) | ALDH1A1L3MBTL1GRM4KLKB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113692405-A | Derivatives of N- ((heteroaryl) methyl) -1-tosyl-1H-pyrazole-3-carboxamide as KV3 potassium channel activators for the treatment of neurological or psychiatric disorders | H.隆德贝克有限公司 | 2021-11-23 | — | — | CN | claimed |
| US-20220220095-A1 | N-((HETEROARYL)METHYL)-1-TOSYL-1H-PYRAZOLE-3-CARBOXAMIDE DERIVATIVES AS Kv3 POTASSIUM CHANNEL ACTIVATORS FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H LUNDBECK AS (DK) | 2022-07-14 | — | — | US | disclosed |
| US-20220220095-A1 | N-((HETEROARYL)METHYL)-1-TOSYL-1H-PYRAZOLE-3-CARBOXAMIDE DERIVATIVES AS Kv3 POTASSIUM CHANNEL ACTIVATORS FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H LUNDBECK AS (DK) | 2022-07-14 | — | — | US | disclosed |
| CN-113692405-A | Derivatives of N- ((heteroaryl) methyl) -1-tosyl-1H-pyrazole-3-carboxamide as KV3 potassium channel activators for the treatment of neurological or psychiatric disorders | H.隆德贝克有限公司 | 2021-11-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220220095-A1 | N-((HETEROARYL)METHYL)-1-TOSYL-1H-PYRAZOLE-3-CARBOXAMIDE DERIVATIVES AS Kv3 POTASSIUM CHANNEL ACTIVATORS FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | KCNA3, KCNK3, KCND3 | MEN1 1231/4885KMT2A 153/4885HSD17B10 4429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.