Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.42 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 6/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL602419 | 0.82 | SLC22A12 (0.32) | IMPDH2IMPDH1CYP19A1SLC22A12 | |
| Hydrochloric Acid SCHEMBL3922779 | 0.79 | ACP3 (0.32) | SLC22A12 | |
| Hydrochloric Acid SCHEMBL16563140 | 0.78 | BCHE (0.46) | CYP19A1BCHEACHEKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL3922774 | 0.78 | — | — | |
| SCHEMBL18012027 | 0.76 | BCHE (0.47) | BCHEACHEKDM4EALDH1A1GAA | |
| SCHEMBL29489135 | 0.74 | IMPDH2 (0.64) | IMPDH2IMPDH1ARCYP19A1SLC22A12 | |
| SCHEMBL151936 | 0.74 | IMPDH2 (0.64) | IMPDH2IMPDH1ARCYP19A1SLC22A12 | |
| SCHEMBL11193357 | 0.72 | IMPDH2 (0.61) | IMPDH2IMPDH1ARCYP19A1SLC22A12 | |
| Hydrochloric Acid SCHEMBL2866117 | 0.71 | BCHE (0.41) | NCOA3BCHEACHEKDM4EMAPT | |
| SCHEMBL11228244 | 0.70 | IMPDH2 (0.59) | IMPDH2IMPDH1ARCYP19A1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8014056-B2 | Display element and method of driving the same | KONICA MINOLTA HOLDINGS, INC. (JP) | 2011-09-06 | — | — | US | disclosed |
| US-20100091353-A1 | DISPLAY ELEMENT AND METHOD OF DRIVING THE SAME | KONICA MINOLTA HOLDINGS, INC. (JP) | 2010-04-15 | — | — | US | disclosed |
| EP-2096490-A1 | DISPLAY ELEMENT AND METHOD OF DRIVING THE SAME | Konica Minolta Holdings, Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |