SCHEMBL246240

SCHEMBL246240

O=C(Oc1cccc(C(c2ccccc2)(c2ccccc2)c2ccccc2)c1C(c1ccccc1)(c1ccccc1)c1ccccc1)Oc1cccc(C(c2ccccc2)(c2ccccc2)c2ccccc2)c1C(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.40
HPGD P15428 4/20 0.40
HSD17B10 Q99714 4/20 0.40
TDP1 Q9NUW8 2/20 0.36
ATM Q13315 1/20 0.36
ALDH1A1 P00352 2/20 0.35
ESR1 P03372 1/20 0.35
ITGB3 P05106 1/20 0.35
ITGA2B P08514 1/20 0.35
HMGB1 P09429 1/20 0.35
TSHR P16473 1/20 0.35
GGT1 P19440 1/20 0.35
PTGS1 P23219 1/20 0.35
PTGS2 P35354 1/20 0.35
BLM P54132 1/20 0.35
NAPRT Q6XQN6 1/20 0.35
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA7 P43166 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL246241 0.90 TDP1 (0.36) KDM4EHPGDHSD17B10TDP1ATM
SCHEMBL19181694 0.86 KDM4E (0.44) KDM4EHPGDHSD17B10TDP1ATM
SCHEMBL1157159 0.80 HPGD (0.40) KDM4EHPGDHSD17B10TDP1ATM
SCHEMBL246295 0.80 HSD17B10 (0.40) KDM4EHPGDHSD17B10TDP1ATM
SCHEMBL247099 0.78 TDP1 (0.40) KDM4EHPGDHSD17B10TDP1ATM
SCHEMBL27996459 0.75 TSHR (0.43) ALDH1A1ESR1TSHRKCNN4MAPK1
SCHEMBL27516773 0.75 TDP1 (0.42) KDM4EHPGDHSD17B10TDP1ATM
SCHEMBL245087 0.73 ATM (0.37) KDM4EHPGDHSD17B10TDP1ATM
SCHEMBL1673995 0.72 TDP1 (0.47) KDM4EHPGDHSD17B10TDP1ATM
SCHEMBL1157161 0.71 FABP4 (0.37) KDM4EHPGDHSD17B10TDP1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6734278-B2 MELT ESTER INTERCHANGE BAYER AKTIENGESELLSCHAFT (DE) 2004-05-11 US claimed
US-20030139564-A1 Production of polyester carbonates BAYER AKTIENGESELLSCHAFT (DE) 2003-07-24 US claimed
EP-3174935-B1 COPOLYCARBONATE COMPOUNDS WITH CYCLIC AND LINEAR OLIGOMERS AND IMPROVED OPTICAL PROPERTIES COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2023-06-21 EP disclosed
EP-3174934-B1 COPOLYCARBONATE COMPOUNDS WITH CYCLIC AND LINEAR OLIGOMERS AND IMPROVED RHEOLOGICAL PROPERTIES COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2023-06-14 EP disclosed
EP-3227374-B1 COPOLYCARBONATE COMPOUNDS WITH IMPROVED RHEOLOGICAL AND OPTICAL PROPERTIES CONTAINING DIGLYCEROLESTER COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2022-06-01 EP disclosed
US-10272654-B2 Polycarbonate composition having improved flame resistance for extrusion applications COVESTRO DEUTSCHLAND AG (DE) 2019-04-30 US disclosed
US-9676716-B2 Polycarbonate having improved thermal and mechanical properties and reduced coefficients of thermal expansion COVESTRO DEUTSCHLAND AG (DE) 2017-06-13 US disclosed
US-20150232644-A1 PRODUCTS WITH IMPROVED NON-FLAMMABILITY COVESTRO DEUTSCHLAND AG (DE) 2015-08-20 US disclosed
US-8969477-B2 Polycarbonate compositions having improved mechanical properties BAYER MATERIALSCIENCE AG (DE) 2015-03-03 US disclosed
US-8507635-B2 Modified polycarbonates having improved surface properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-08-13 US disclosed
US-8470934-B2 Polycarbonate compositions having improved surface hardness BAYER MATERIALSCIENCE AG (DE) 2013-06-25 US disclosed
US-6734278-B2 MELT ESTER INTERCHANGE BAYER AKTIENGESELLSCHAFT (DE) 2004-05-11 US disclosed
US-20040030090-A1 Polycarbonates, polyester carbonates and polyesters with special branched terminal groups BAYER AKTIENGESELLSCHAFT (DE) 2004-02-12 US disclosed
US-6646099-B2 Production and use of polyester carbonates BAYER AKTIENGESELLSCHAFT (DE) 2003-11-11 US disclosed
US-20030204042-A1 Production and use of high molecular weight aliphatic polycarbonates BAYER AKTIENGESELLSCHAFT (DE) 2003-10-30 US disclosed
US-20030139564-A1 Production of polyester carbonates BAYER AKTIENGESELLSCHAFT (DE) 2003-07-24 US disclosed
US-20030105272-A1 Production and use of polyester carbonates BAYER AKTIENGESELLSCHAFT (DE) 2003-06-05 US disclosed
US-20030055201-A1 Process for optimising the production of polycarbonate by melt transesterification BAYER AKTIENGESELLSCHAFT (DE) 2003-03-20 US disclosed
US-20030027971-A1 Preparation of copolycarbonates BAYER AKTIENGESELLSCHAFT (DE) 2003-02-06 US disclosed
US-20020177684-A1 Process for producing polycarbonates BAYER AKTIENGESELLSCHAFT (DE) 2002-11-28 US disclosed