Sugi Predict

Sugi Predict / Compounds / SCHEMBL2462894

SCHEMBL2462894

SCHEMBL2462894

N[N+]12C=CN=CC1=C(c1ccc3ccccc3c1)N=C2c1cccc(OCc2ccccc2)c1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 1/20 0.41
▸ F9 P00740 1/20 0.39
▸ F10 P00742 1/20 0.39
▸ DHODH Q02127 4/20 0.37
▸ MAOB P27338 2/20 0.37
▸ CDC7 O00311 1/20 0.37
▸ IGF1R P08069 1/20 0.37
▸ PDE10A Q9Y233 1/20 0.36
▸ BACE1 P56817 1/20 0.36
▸ CYP3A4 P08684 1/20 0.36
▸ PIK3CD O00329 1/20 0.35
▸ PIK3CA P42336 1/20 0.35
▸ PIK3CB P42338 1/20 0.35
▸ PIK3CG P48736 1/20 0.35
▸ PRKDC P78527 1/20 0.35
▸ NR1H2 P55055 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2460398 0.92 MAOB (0.41) F9F10DHODHMAOBIGF1R
SCHEMBL2460148 0.89 CFD (0.42) MAOBIGF1RBACE1PIK3CDPIK3CA
SCHEMBL2459704 0.89 TSHR (0.39) F9F10DHODHMAOBIGF1R
SCHEMBL2461277 0.88 ALOX5 (0.40) ALOX5F9F10DHODHPDE10A
SCHEMBL2465920 0.87 BACE1 (0.39) ALOX5F9F10DHODHMAOB
SCHEMBL2459477 0.85 MRGPRX4 (0.43) DHODHMAOB
SCHEMBL2460199 0.85 PARP10 (0.45) ALOX5DHODHMAOB
SCHEMBL2460200 0.85 MAOB (0.37) F9F10DHODHMAOBIGF1R
SCHEMBL2461522 0.83 ALOX5 (0.34) ALOX5MAOB
SCHEMBL2460741 0.83 SMPD1 (0.36) ALOX5F9F10DHODHMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP claimed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US claimed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US claimed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US claimed
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 ALOX5 4577/4885F9 4236/4885F10 3668/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 ALOX5 4577/4885F9 4236/4885F10 3668/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 ALOX5 4577/4885F9 4236/4885F10 3668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.