Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | DAO | P14920 | 1/20 | 0.65 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.61 |
| ▸ | CES2 | O00748 | 3/20 | 0.61 |
| ▸ | CES1 | P23141 | 3/20 | 0.61 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL548684 | 0.95 | TSHR (0.72) | TSHRDAONAPRTTP53SRD5A2 | |
| Naphthalene SCHEMBL11360560 | 0.89 | TSHR (0.82) | TSHRDAONAPRTTP53SRD5A2 | |
| Naphthalene SCHEMBL498190 | 0.89 | TSHR (0.82) | TSHRDAONAPRTTP53SRD5A2 | |
| Naphthalene SCHEMBL28954790 | 0.89 | TSHR (0.82) | TSHRDAONAPRTTP53SRD5A2 | |
| Beta-Naphtoic Acid SCHEMBL727615 | 0.86 | CES2 (0.65) | TP53CES2CES1ALOX15ALDH1A1 | |
| Benzoic Acid SCHEMBL1522973 | 0.86 | TSHR (0.88) | TSHRDAONAPRTTP53SRD5A2 | |
| Benzoic Acid SCHEMBL20574965 | 0.86 | TSHR (0.88) | TSHRDAONAPRTTP53SRD5A2 | |
| Benzoic Acid SCHEMBL28791118 | 0.86 | TSHR (0.88) | TSHRDAONAPRTTP53SRD5A2 | |
| Benzoic Acid SCHEMBL434647 | 0.86 | TSHR (0.88) | TSHRDAONAPRTTP53SRD5A2 | |
| Benzoic Acid SCHEMBL29182064 | 0.86 | TSHR (0.88) | TSHRDAONAPRTTP53SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115580-A1 | A PROCESS FOR MAKING AN ARRAY | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2011-09-22 | — | — | WO | disclosed |