Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | APP | P05067 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22754409 | 0.83 | ALDH1A1 (0.38) | TP53TDP1ALDH1A1TSHRKDM4E | |
| SCHEMBL12288721 | 0.80 | ALDH1A3 (0.39) | TP53TDP1ALDH1A1KDM4EGAA | |
| SCHEMBL7921915 | 0.80 | CYP2A6 (0.45) | TP53TDP1ALDH1A1KDM4EGAA | |
| SCHEMBL10364078 | 0.79 | ALDH1A1 (0.49) | ALDH1A1TSHRKDM4EGAACYP3A4 | |
| SCHEMBL7526844 | 0.78 | ERN1 (0.34) | ALDH1A1TSHRKDM4EGAAMAPT | |
| SCHEMBL22877218 | 0.77 | CYP3A4 (0.33) | TP53TDP1CYP3A4ADRA2A | |
| SCHEMBL5084622 | 0.75 | TDP1 (0.44) | TP53TDP1ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL25685746 | 0.74 | — | — | |
| SCHEMBL19773272 | 0.73 | TP53 (0.31) | TP53TDP1ESR1ESR2 | |
| SCHEMBL87447 | 0.73 | ALOX5 (0.47) | TP53TDP1ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022240830-A1 | C-LINKED INHIBITORS OF ENL/AF9 YEATS | BRIDGE MEDICINES (US) | 2022-11-17 | — | — | WO | disclosed |