Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | HTR2B | P41595 | 4/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25144905 | 0.81 | ADRB1 (0.50) | OPRM1HTR2AHTR2CHTR2B | |
| SCHEMBL25144854 | 0.81 | ADRB1 (0.50) | OPRM1HTR2AHTR2CHTR2B | |
| SCHEMBL19280231 | 0.79 | ALOX5 (0.47) | OPRM1MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL19996264 | 0.79 | ALOX5 (0.47) | OPRM1MEN1KMT2AHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL18043593 | 0.79 | ADRB1 (0.49) | OPRM1HTR2AHTR2CHTR2B | |
| SCHEMBL29327284 | 0.79 | HTR2C (0.50) | OPRM1MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL25144858 | 0.79 | HTR2A (0.50) | OPRM1MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL23777634 | 0.79 | HTR2A (0.50) | OPRM1MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL30796889 | 0.79 | OPRM1 (1.00) | OPRM1MEN1KMT2AHTR2AOPRD1 | |
| SCHEMBL27456474 | 0.79 | OPRM1 (1.00) | OPRM1MEN1KMT2AHTR2AOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9750738-B2 | Arylpiperazine opioid receptor antagonists | RESEARCH TRIANGLE INSTITUTE (US) | 2017-09-05 | — | — | US | disclosed |
| US-20160095854-A1 | ARYLPIPERAZINE OPIOID RECEPTOR ANTAGONISTS | RESEARCH TRIANGLE INSTITUTE (US) | 2016-04-07 | — | — | US | disclosed |
| US-9273027-B2 | Arylpiperazine opioid receptor antagonists | RESEARCH TRIANGLE INSTITUTE (US) | 2016-03-01 | — | — | US | disclosed |
| EP-2539706-B1 | ARYLPIPERAZINE OPIOID RECEPTOR ANTAGONISTS | RES TRIANGLE INST (US) | 2015-03-04 | — | — | EP | disclosed |
| EP-2539706-A1 | ARYLPIPERAZONE OPIOID RECEPTOR ANTAGONISTS | Research Triangle Institute (US) | 2013-01-02 | — | — | EP | disclosed |
| US-20120295919-A1 | ARYLPIPERAZINE OPIOID RECEPTOR ANTAGONISTS | RESEARCH TRIANGLE INSTITUTE (US) | 2012-11-22 | — | — | US | disclosed |
| WO-2011106039-A1 | ARYLPIPERAZONE OPIOID RECEPTOR ANTAGONISTS | RESEARCH TRIANGLE INSTITUTE (US) | 2011-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295919-A1 | ARYLPIPERAZINE OPIOID RECEPTOR ANTAGONISTS | OPRL1, OPRM1, OPRD1 | OPRM1 2/4885MEN1 4884/4885KMT2A 1908/4885 |
| US-20160095854-A1 | ARYLPIPERAZINE OPIOID RECEPTOR ANTAGONISTS | OPRL1, OPRM1, OPRD1 | OPRM1 2/4885MEN1 4884/4885KMT2A 1875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.