Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27360925 | 0.81 | MAPT (0.45) | MAPTHTTTAAR1P2RX7NPC1 | |
| SCHEMBL21675477 | 0.77 | MAPT (0.46) | MAPTHTTP2RX7NPC1RAB9A | |
| SCHEMBL30461968 | 0.76 | MAPT (0.50) | MAPTHTTP2RX7NPC1RAB9A | |
| SCHEMBL4750832 | 0.76 | MAPT (0.50) | MAPTHTTP2RX7NPC1RAB9A | |
| SCHEMBL245209 | 0.72 | MAPT (0.50) | MAPTHTTP2RX7NPC1RAB9A | |
| SCHEMBL9777532 | 0.71 | MAPT (0.42) | MAPTHTTP2RX7ADRB2ADRB1 | |
| SCHEMBL19399594 | 0.71 | MAPT (0.45) | MAPTHTTP2RX7NPC1RAB9A | |
| SCHEMBL17716129 | 0.71 | MAPT (0.45) | MAPTHTTP2RX7NPC1RAB9A | |
| SCHEMBL11268371 | 0.70 | MAPT (0.41) | MAPTHTTP2RX7ADRB2ADRB1 | |
| SCHEMBL14930874 | 0.69 | ALDH1A1 (0.50) | MAPTHTTP2RX7NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226408-A1 | NOVEL ERGOLINES AND METHODS OF TREATING MOOD DISORDERS | GILGAMESH PHARMACEUTICALS, INC. (US) | 2022-10-27 | — | — | WO | disclosed |