Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18108807 | 0.83 | ALDH1A1 (0.41) | ALDH1A1TSHRCYP3A4CYP2C19AAK1 | |
| SCHEMBL18108809 | 0.81 | ALDH1A1 (0.41) | ALDH1A1TSHRCYP3A4CYP2C19AAK1 | |
| SCHEMBL16176806 | 0.81 | ALDH1A1 (0.41) | ALDH1A1TSHRCYP3A4CYP2C19AAK1 | |
| SCHEMBL16463458 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TSHRCYP3A4CYP2C19KDM4E | |
| SCHEMBL19949448 | 0.73 | ATR (0.47) | ALDH1A1TSHRCYP3A4CYP2C19AAK1 | |
| SCHEMBL13163125 | 0.72 | ALDH1A1 (0.41) | ALDH1A1TSHRCYP3A4CYP2C19KMT2A | |
| SCHEMBL263757 | 0.72 | ALDH1A1 (0.49) | ALDH1A1TSHRCYP3A4CYP2C19KMT2A | |
| SCHEMBL16462026 | 0.71 | ALDH1A1 (0.43) | ALDH1A1TSHRCYP3A4CYP2C19KDM4E | |
| SCHEMBL19949449 | 0.70 | ATR (0.45) | ALDH1A1TSHRCYP3A4CYP2C19AAK1 | |
| SCHEMBL2466382 | 0.67 | IRAK4 (0.35) | ALDH1A1TSHRKDM4EKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012956-B2 | Tropane compounds | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | claimed |
| US-20090163471-A1 | Tropane compounds | EXELIXIS, INC. | 2009-06-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163471-A1 | Tropane compounds | ADRA1B, ADRA2B, ADRB2 | ALDH1A1 323/4885TSHR 172/4885MKNK1 4784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.