Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.53 |
| ▸ | CLK2 | P49760 | 3/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.53 |
| ▸ | CLK1 | P49759 | 2/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.53 |
| ▸ | CLK3 | P49761 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.53 |
| ▸ | PIM1 | P11309 | 6/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.53 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 5/20 | 0.51 |
| ▸ | GSK3A | P49840 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460335 | 0.88 | FGFR1 (0.53) | GSK3BCDK5DYRK1ACLK2CLK4 | |
| SCHEMBL2462858 | 0.76 | S1PR1 (0.49) | S1PR1GAA | |
| SCHEMBL2461143 | 0.75 | GSK3B (0.53) | GSK3BCDK5DYRK1ACLK2CLK4 | |
| SCHEMBL13332229 | 0.74 | S1PR1 (0.60) | GSK3BCDK5DYRK1ACLK2CLK4 | |
| SCHEMBL2457606 | 0.73 | GSK3B (0.58) | GSK3BCDK5DYRK1ACLK2CLK4 | |
| SCHEMBL14514473 | 0.73 | GSK3B (0.58) | GSK3BCDK5DYRK1ACLK2CLK4 | |
| SCHEMBL2029580 | 0.72 | CLK1 (0.55) | GSK3BCDK5DYRK1ACLK2CLK4 | |
| SCHEMBL2463725 | 0.72 | GSK3B (0.53) | GSK3BCDK5DYRK1ACLK2CLK4 | |
| SCHEMBL5014101 | 0.71 | CLK1 (0.64) | GSK3BCDK5DYRK1ACLK2CLK4 | |
| SCHEMBL6423944 | 0.71 | SMN1; SMN2 (0.51) | S1PR1KDM4EMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-09-29 | — | — | US | disclosed |
| WO-2010068287-A2 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, MET | GSK3B 817/4885CDK5 1513/4885DYRK1A 4134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.