Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 13/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24640536 | 0.79 | CDK4 (0.42) | PARP1P2RX7 | |
| SCHEMBL30720013 | 0.77 | PARP1 (0.47) | PARP1P2RX7PARP10PARP11 | |
| SCHEMBL30720004 | 0.74 | PARP1 (0.39) | PARP1P2RX7PARP10PARP11 | |
| SCHEMBL24640572 | 0.73 | ADRB2 (0.38) | POLBADRB2NCF1SCN9A | |
| SCHEMBL30104836 | 0.71 | PARP1 (0.38) | PARP1PARP10PARP11 | |
| SCHEMBL30141892 | 0.68 | PTGS2 (0.45) | POLB | |
| SCHEMBL13173568 | 0.67 | ALDH1A1 (0.38) | POLB | |
| SCHEMBL31244795 | 0.66 | POLB (0.35) | POLB | |
| SCHEMBL18136193 | 0.65 | POLB (0.52) | POLB | |
| SCHEMBL24640538 | 0.65 | HTR2C (0.42) | POLBADRB2NCF1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |