SCHEMBL2464096

SCHEMBL2464096

Nc1cc(-c2ccccc2Cl)nc(OC(=O)O)c1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.46
HSP90AB1 P08238 1/20 0.46
ALPL P05186 1/20 0.42
ADORA2A P29274 4/20 0.40
ADORA1 P30542 4/20 0.40
PRKDC P78527 1/20 0.40
ATR Q13535 1/20 0.40
ABL1 P00519 1/20 0.39
VCP P55072 1/20 0.38
KDM5B Q9UGL1 1/20 0.38
MAOB P27338 1/20 0.38
TSPO P30536 1/20 0.38
MAPK14 Q16539 1/20 0.38
LTB4R Q15722 2/20 0.37
IKBKB O14920 1/20 0.37
TACR3 P29371 1/20 0.37
NPC1 O15118 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MEN1 O00255 1/20 0.37
CYP1A2 P05177 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2467530 0.87 ADORA2A (0.40) ADORA2AADORA1ATRVCPKDM5B
SCHEMBL2469200 0.87 PRKDC (0.39) ADORA2AADORA1PRKDCATRVCP
SCHEMBL2470000 0.86 ACHE (0.45) HSP90AA1HSP90AB1ADORA2AADORA1SMN1; SMN2
SCHEMBL2468346 0.85 HSP90AA1 (0.47) HSP90AA1HSP90AB1ALPLNPC1SMN1; SMN2
SCHEMBL2468292 0.85 AGPAT2 (0.41) HSP90AA1HSP90AB1
SCHEMBL2468802 0.85 HSP90AA1 (0.52) HSP90AA1HSP90AB1ADORA2AADORA1ATR
SCHEMBL2466413 0.83 GRM2 (0.41) HSP90AA1HSP90AB1KDM4E
SCHEMBL2465720 0.83 CDC7 (0.39) HSP90AA1HSP90AB1NPC1SMN1; SMN2HPGD
SCHEMBL2465856 0.82 PPARA (0.36) HSP90AA1HSP90AB1ALPLMEN1KMT2A
SCHEMBL9938973 0.81 CYP3A4 (0.40) HSP90AA1HSP90AB1ALPLABL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed