Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | PTPRB | P23467 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28741495 | 1.00 | ALDH1A1 (0.51) | ALDH1A1ESR1ESR2ACACBSLC7A5 | |
| Hydrochloric Acid SCHEMBL3498236 | 0.87 | LTA4H (0.58) | ALDH1A1L3MBTL1PPARGPPARALTA4H | |
| Hydrochloric Acid SCHEMBL3498238 | 0.87 | LTA4H (0.58) | ALDH1A1L3MBTL1PPARGPPARALTA4H | |
| SCHEMBL15019650 | 0.86 | LOXL2 (0.59) | ALDH1A1SLC7A5TDP1LNPEPERAP2 | |
| SCHEMBL15019652 | 0.86 | LOXL2 (0.59) | ALDH1A1SLC7A5TDP1LNPEPERAP2 | |
| SCHEMBL14139328 | 0.86 | SLC7A5 (0.44) | ALDH1A1ACACBSLC7A5TDP1L3MBTL1 | |
| SCHEMBL12028471 | 0.86 | ALDH1A1 (0.51) | ALDH1A1ESR1ESR2SLC7A5PTGS2 | |
| SCHEMBL16060244 | 0.86 | ALDH1A1 (0.51) | ALDH1A1ESR1ESR2ACACBSLC7A5 | |
| SCHEMBL5916451 | 0.86 | ALDH1A1 (0.51) | ALDH1A1ESR1ESR2SLC7A5PTGS2 | |
| SCHEMBL16542135 | 0.86 | ALDH1A1 (0.51) | ALDH1A1ESR1ESR2SLC7A5PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220362396-A1 | AMINO-PYRAZINECARBOXAMIDE COMPOUNDS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220362396-A1 | AMINO-PYRAZINECARBOXAMIDE COMPOUNDS, CONJUGATES, AND USES THEREOF | TGFBR2, SMAD2, ACVR2A | ALDH1A1 1720/4885ESR1 3496/4885ESR2 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.