SCHEMBL2465146

SCHEMBL2465146

Nc1cc(-c2nc3ccccc3o2)nc(C(=O)O)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.45
MAPT P10636 8/20 0.45
ALDH1A1 P00352 7/20 0.45
KDM4E B2RXH2 6/20 0.45
MEN1 O00255 4/20 0.45
KMT2A Q03164 4/20 0.45
ALPL P05186 1/20 0.45
POLB P06746 1/20 0.45
ALPI P09923 1/20 0.45
ALPG P10696 1/20 0.45
RECQL P46063 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
NPC1 O15118 7/20 0.43
ATM Q13315 1/20 0.43
AGPAT2 O15120 1/20 0.41
HPGD P15428 6/20 0.41
TP53 P04637 5/20 0.41
HSD17B10 Q99714 4/20 0.41
SMN1; SMN2 Q16637 4/20 0.41
PKM P14618 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2465148 0.81 RAB9A (0.42) RAB9AMAPTALDH1A1KDM4EMEN1
SCHEMBL6167286 0.81 NPC1 (0.50) RAB9AMAPTALDH1A1KDM4EMEN1
SCHEMBL2468804 0.80 KDM4E (0.48) RAB9AMAPTALDH1A1KDM4EMEN1
SCHEMBL2469999 0.78 MAP2K3 (0.51) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL3329998 0.75 CTRC (0.54) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL2465973 0.74 KDM4E (0.47) RAB9AMAPTALDH1A1KDM4EMEN1
SCHEMBL2464095 0.74 HSP90AA1 (0.49) RAB9AKDM4EMEN1KMT2AALPL
SCHEMBL3330104 0.74 CA12 (0.36) RAB9AKDM4EMEN1KMT2ANPC1
SCHEMBL2465823 0.73 CCR1 (0.49) MAPTKDM4EKMT2AALPLPOLB
SCHEMBL3333535 0.72 CYP1A1 (0.50) RAB9AMAPTALDH1A1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
US-8962523-B2 Herbicide/safener combination BAYER CROPSCIENCE AG (DE) 2015-02-24 US disclosed
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2015-02-19 US disclosed
CN-102300459-A Herbicide-safener combination 2011-12-28 CN disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
US-20100137137-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 US disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed
CN-1245401-C 6-aryl-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2006-03-15 CN disclosed
EP-1414814-B1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2005-02-02 EP disclosed
CN-1551876-A 6-aryl-4-aminopicolinates and their use as herbicides �ݶ�ũ�����޹�˾ 2004-12-01 CN disclosed
US-6784137-B2 SUCH AS 5,6-DICHLOROPYRIDINE-2-CARBOXYLIC ACID-N-OXIDE FOR PREEMERGENCE APPLICATION DOW AGROSCIENCES LLC 2004-08-31 US disclosed
EP-1414814-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2004-05-06 EP disclosed
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2003-06-19 US disclosed
WO-2003011853-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2003-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137137-A1 HERBICIDE/SAFENER COMBINATION DDT, CYP2W1, GAP43 RAB9A 3634/4885MAPT 4056/4885ALDH1A1 209/4885
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides AADAC, DDT, AADAT RAB9A 2477/4885MAPT 526/4885ALDH1A1 713/4885
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION DDT, CYP2W1, GAP43 RAB9A 3634/4885MAPT 4056/4885ALDH1A1 209/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.