Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30748963 | 0.85 | ALOX5 (0.35) | PRKCIALOX5 | |
| SCHEMBL12611813 | 0.78 | PRKCI (0.30) | PRKCI | |
| SCHEMBL17984590 | 0.77 | PRSS1 (0.36) | — | |
| SCHEMBL27473717 | 0.77 | PRKCI (0.36) | PRKCIALOX5 | |
| SCHEMBL28007567 | 0.71 | LMNA (0.34) | ALOX5 | |
| SCHEMBL27887045 | 0.71 | LMNA (0.39) | ALOX5 | |
| SCHEMBL28018125 | 0.71 | TNFSF11 (0.38) | ALOX5TNFSF11 | |
| SCHEMBL29861340 | 0.70 | HTT (0.33) | — | |
| SCHEMBL4944664 | 0.69 | KDM4E (0.39) | ALOX5 | |
| SCHEMBL27598250 | 0.69 | LMNA (0.33) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370424-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2011-10-05 | — | — | EP | disclosed |