Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398770 | 0.81 | LMNA (0.39) | KDM4ELMNASMN1; SMN2CYP2C9CHRNB2 | |
| SCHEMBL11253057 | 0.81 | CHRNB2 (0.36) | LMNASMN1; SMN2CHRNB2CHRNA4POLB | |
| SCHEMBL7994968 | 0.80 | ATR (0.34) | KDM4ETDP1LMNASMN1; SMN2TSHR | |
| SCHEMBL28711249 | 0.79 | RAB9A (0.36) | LMNASMN1; SMN2TSHRADRA1ACHRNB2 | |
| SCHEMBL22583086 | 0.79 | ALDH1A1 (0.39) | KDM4ELMNASMN1; SMN2ALOX5TSHR | |
| SCHEMBL4535342 | 0.78 | CHRNB2 (0.34) | KDM4ETDP1LMNASMN1; SMN2CYP2C9 | |
| SCHEMBL28018125 | 0.77 | TNFSF11 (0.38) | KDM4ECYP3A4TDP1ALOX12LMNA | |
| SCHEMBL28007567 | 0.77 | LMNA (0.34) | KDM4ECYP3A4TDP1ALOX12LMNA | |
| SCHEMBL27887045 | 0.77 | LMNA (0.39) | KDM4ECYP3A4TDP1ALOX12LMNA | |
| SCHEMBL27746548 | 0.76 | ALDH1A1 (0.38) | KDM4ECYP3A4TDP1LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105037281-A | Preparation method for 3-(3-fluorophenoxyl)pyrazine-2-carboxylic acid | CHANGSHA SHENCHENG BIOLOG SCIENCE & TECHNOLOGY CO LTD | 2015-11-11 | — | — | CN | disclosed |
| CN-105017166-A | Preparation method of 3-(3-bromine phenoxy) pyrazine-2-carboxylic acid | CHANGSHA SHENCHENG BIOLOG TECHNOLOGY CO LTD | 2015-11-04 | — | — | CN | disclosed |
| CN-104961690-A | Preparation method of 3-(4-fluorophenoxy) pyrazine-2-carboxylic acid | CHANGSHA SHENCHENG BIOTECHNOLOGY CO LTD | 2015-10-07 | — | — | CN | disclosed |
| CN-104961691-A | Preparation method of 3-(2-fluorophenoxy) pyrazine-2-carboxylic acid | CHANGSHA SHENCHENG BIOTECHNOLOGY CO LTD | 2015-10-07 | — | — | CN | disclosed |
| EP-1958946-A1 | PYRIDAZINE COMPOUND AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2008-08-20 | — | — | EP | disclosed |