SCHEMBL2466331

SCHEMBL2466331

Nc1cc(-c2ccncc2)nc(C(=O)O)c1Cl

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAP2K3 P46734 3/20 0.51
MAPT P10636 1/20 0.46
DHODH Q02127 1/20 0.43
CASP1 P29466 2/20 0.42
ALDH1A1 P00352 1/20 0.42
GAA P10253 1/20 0.42
PRKDC P78527 1/20 0.41
ATR Q13535 1/20 0.41
MAPK14 Q16539 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
CTRC Q99895 2/20 0.38
SRC P12931 1/20 0.38
KDR P35968 1/20 0.38
MAPK1 P28482 1/20 0.38
CCNC P24863 1/20 0.37
CDK8 P49336 1/20 0.37
CDC7 O00311 1/20 0.37
DBF4 Q9UBU7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2469999 0.88 MAP2K3 (0.51) MAP2K3MAPTDHODHCASP1ALDH1A1
SCHEMBL2468156 0.86 CTRC (0.51) MAPTDHODHCASP1ALDH1A1ATR
SCHEMBL3329998 0.85 CTRC (0.54) MAP2K3MAPTDHODHALDH1A1TDP1
SCHEMBL27521806 0.84 CYP19A1 (0.49) DHODHGAAATR
SCHEMBL16075391 0.84 CTRC (0.39) MAP2K3MAPTDHODHALDH1A1ATR
SCHEMBL2466247 0.84 DHODH (0.49) MAPTDHODHALDH1A1ATRTDP1
SCHEMBL2466881 0.84 DHODH (0.49) MAPTDHODHALDH1A1GAAATR
SCHEMBL16075484 0.84 MCL1 (0.51) DHODHCASP1
SCHEMBL3324372 0.83 CASP1 (0.47) MAPTDHODHCASP1ALDH1A1
Ethylene SCHEMBL27521038 0.82 POLB (0.43) MAP2K3PRKDCATRTDP1CTRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
US-8962523-B2 Herbicide/safener combination BAYER CROPSCIENCE AG (DE) 2015-02-24 US disclosed
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2015-02-19 US disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
US-20100137137-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 US disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed
CN-1245401-C 6-aryl-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2006-03-15 CN disclosed
EP-1414814-B1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2005-02-02 EP disclosed
CN-1551876-A 6-aryl-4-aminopicolinates and their use as herbicides �ݶ�ũ�����޹�˾ 2004-12-01 CN disclosed
US-6784137-B2 SUCH AS 5,6-DICHLOROPYRIDINE-2-CARBOXYLIC ACID-N-OXIDE FOR PREEMERGENCE APPLICATION DOW AGROSCIENCES LLC 2004-08-31 US disclosed
EP-1414814-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2004-05-06 EP disclosed
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2003-06-19 US disclosed
WO-2003011853-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2003-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137137-A1 HERBICIDE/SAFENER COMBINATION DDT, CYP2W1, GAP43 MAP2K3 2373/4885MAPT 4056/4885DHODH 237/4885
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides AADAC, DDT, AADAT MAP2K3 2728/4885MAPT 526/4885DHODH 2462/4885
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION DDT, CYP2W1, GAP43 MAP2K3 2373/4885MAPT 4056/4885DHODH 237/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.