Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2470413 | 1.00 | ALDH1A1 (0.43) | ALDH1A1ALOX15HDAC3HDAC4HDAC1 | |
| SCHEMBL10790255 | 0.90 | ALDH1A1 (0.46) | ALDH1A1ALOX15HDAC3HDAC4HDAC1 | |
| SCHEMBL3345076 | 0.78 | KCNN4 (0.54) | ALDH1A1ALOX15HDAC3HDAC4HDAC1 | |
| SCHEMBL8778104 | 0.75 | KCNN4 (0.44) | ALDH1A1ALOX15HDAC3HDAC4HDAC1 | |
| SCHEMBL18035828 | 0.75 | KCNN4 (0.56) | ALDH1A1ALOX15HDAC3HDAC4HDAC1 | |
| SCHEMBL8254374 | 0.75 | KCNN4 (0.44) | ALDH1A1ALOX15HDAC3HDAC4HDAC1 | |
| SCHEMBL14916526 | 0.74 | ALDH1A1 (0.41) | ALDH1A1ALOX15HDAC3HDAC4HDAC1 | |
| SCHEMBL5049524 | 0.73 | SLC6A4 (0.41) | ALDH1A1ALOX15HDAC3HDAC4HDAC1 | |
| SCHEMBL27776663 | 0.73 | KCNN4 (0.59) | ALDH1A1ALOX15HDAC3HDAC4HDAC1 | |
| SCHEMBL2037144 | 0.72 | ALDH1A1 (0.48) | ALDH1A1ALOX15HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083920-B1 | N-ARYL-HYDROXYALKYLIDENE-CARBOXAMIDE COMPOUNDS AND THEIR USE | WEI EDWARD TAK (US) | 2011-10-05 | — | — | EP | disclosed |
| US-20100041757-A1 | N-ARYL-HYDROXYALKYLIDENE-CARBOXAMIDE COMPOUNDS AND THEIR USE | WEI EDWARD TAK | 2010-02-18 | — | — | US | disclosed |
| EP-2083920-A1 | N-ARYL-HYDROXYALKYLIDENE-CARBOXAMIDE COMPOUNDS AND THEIR USE | Wei, Edward T. (US) | 2009-08-05 | — | — | EP | disclosed |
| US-20080118558-A1 | N-Arylshydroxyalkylidene carboxamide compositions and methods | WEI EDWARD T | 2008-05-22 | — | — | US | disclosed |
| WO-2008056118-A1 | N-ARYL-HYDROXYALKYLIDENE-CARBOXAMIDE COMPOUNDS AND THEIR USE | PAGET, HUGH, CHARLES, EDWARD (GB) | 2008-05-15 | — | — | WO | disclosed |
| US-20070155755-A1 | N-arylshydroxyalkylidene-carboxamide compositions and methods | WEI EDWARD T | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080118558-A1 | N-Arylshydroxyalkylidene carboxamide compositions and methods | TRPV1, OPRL1, HRH2 | ALDH1A1 2587/4885ALOX15 1110/4885HDAC3 1060/4885 |
| US-20070155755-A1 | N-arylshydroxyalkylidene-carboxamide compositions and methods | TRPV1, OPRL1, HRH2 | ALDH1A1 2771/4885ALOX15 1045/4885HDAC3 1058/4885 |
| US-20100041757-A1 | N-ARYL-HYDROXYALKYLIDENE-CARBOXAMIDE COMPOUNDS AND THEIR USE | TRPV1, TRPA1, TRPV2 | ALDH1A1 397/4885ALOX15 902/4885HDAC3 1121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.