Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3147993 | 0.84 | CA12 (0.50) | CLK4NPC1RAB9AALDH1A1RXFP1 | |
| SCHEMBL30335253 | 0.84 | CA12 (0.50) | CLK4NPC1RAB9AALDH1A1RXFP1 | |
| SCHEMBL25195228 | 0.84 | LMNA (0.54) | NPC1RAB9AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL29419008 | 0.84 | LMNA (0.54) | NPC1RAB9AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL1443857 | 0.78 | L3MBTL1 (0.59) | NPC1RAB9AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL13341651 | 0.78 | NPC1 (0.62) | DYRK1ANPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL17992232 | 0.77 | NPC1 (0.44) | CLK4NPC1RAB9AALDH1A1TNKS | |
| SCHEMBL13330991 | 0.77 | NPC1 (0.46) | CLK4NPC1RAB9AMAPT | |
| SCHEMBL14355082 | 0.76 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2RXFP1CYP1A2 | |
| SCHEMBL16656143 | 0.75 | CCR1 (0.67) | NPC1RAB9AALDH1A1TDP1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370426-A1 | N-{[(IR,4S,6R-3-(2-PYRIDINYLCARBONYL)-3-AZABICYCLO [4.1.0]HEPT-4-YL]METHYL}-2-HETEROARYLAMINE DERIVATIVES AND USES THEREOF | Glaxo Group Limited (GB) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010063663-A1 | N-{[(IR,4S,6R-3-(2-PYRIDINYLCARBONYL)-3-AZABICYCLO [4.1.0]HEPT-4-YL] METHYL}-2-HETEROARYLAMINE DERIVATIVES AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2010-06-10 | — | — | WO | disclosed |