Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.47 |
| ▸ | GLS | O94925 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24675927 | 0.90 | GLS (0.44) | ROCK2CYP3A4CYP2D6CYP2C9ROCK1 | |
| SCHEMBL29996911 | 0.89 | ROCK2 (0.49) | ROCK2CYP3A4CYP2D6CYP2C9ROCK1 | |
| SCHEMBL23461821 | 0.89 | ROCK2 (0.49) | ROCK2CYP3A4CYP2D6CYP2C9ROCK1 | |
| SCHEMBL19553568 | 0.86 | KCNA5 (0.45) | ROCK2CYP3A4CYP2D6CYP2C9ROCK1 | |
| SCHEMBL24675183 | 0.85 | ROCK2 (0.49) | ROCK2CYP3A4CYP2D6CYP2C9ROCK1 | |
| SCHEMBL2207089 | 0.85 | MTNR1A (0.51) | CYP2D6POLB | |
| SCHEMBL91150 | 0.84 | CA12 (0.56) | POLB | |
| SCHEMBL3418637 | 0.84 | ALDH1A1 (0.62) | ALDH1A1HTTSMN1; SMN2MMP13POLB | |
| SCHEMBL595225 | 0.84 | CA12 (0.52) | ALDH1A1 | |
| SCHEMBL20946412 | 0.84 | MAPT (0.47) | GLSBRD4ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |