Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24675197 | 1.00 | KDM4E (0.43) | KDM4ENOS1NOS3ROCK2CYP3A4 | |
| SCHEMBL24675190 | 0.86 | KDM4E (0.42) | KDM4ELMNAMAPT | |
| SCHEMBL24675517 | 0.84 | KDM4E (0.47) | KDM4ELMNASMN1; SMN2 | |
| SCHEMBL24675890 | 0.84 | GLS (0.45) | CYP3A4 | |
| SCHEMBL24675891 | 0.83 | CNR1 (0.40) | KDM4ECYP2D6 | |
| SCHEMBL2786701 | 0.82 | LTA4H (0.50) | — | |
| SCHEMBL15110899 | 0.80 | ALDH1A1 (0.46) | KDM4ECYP3A4CYP2D6CYP2C9MAPT | |
| SCHEMBL16923976 | 0.80 | ALDH1A1 (0.46) | KDM4ECYP3A4CYP2D6CYP2C9MAPT | |
| SCHEMBL15126228 | 0.80 | MAOB (0.48) | KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL30856531 | 0.80 | KMT2A (0.57) | KDM4ECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |